风湿

IL-35在自身免疫性疾病中的作用

作者:Sakkas LI, et al. 翻译:北医三院赵金霞 审校:柴静 来源:中国风湿病公众论坛 日期:2018-06-07
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         IL-35在自身免疫性疾病中的作用

关键字:  IL-35 

        摘要:IL-35是一种新的具有重要免疫调节功能的细胞因子。IL-35属于IL-12细胞因子家族成员,包括IL-12、IL-23、IL-27和IL-35。这些细胞因子是具有共享亚基的异二聚体,它们的受体也具有共享亚基。IL-12和IL-23是明确的促炎性细胞因子,IL-35的作用尚不清楚。在小鼠中,IL-35似乎具有抗炎和对自身免疫性炎症疾病的保护作用。IL-35诱导调节性T细胞(Treg)和Bregs亚群的扩增,并介导其抑制功能并抑制Th17细胞。它还上调骨保护素和抑制RANKL的表达,从而抑制骨吸收。在自身免疫性风湿病中,结果并不一致,尽管在系统性红斑狼疮中,IL-35的功能降低。一项研究显示,在银屑病关节炎,一种以外周关节中骨侵蚀和骨形成,脊椎关节骨形成为特征的疾病,血清IL-35水平增加。有关IL-35在人类自身免疫性风湿病中的确切作用还需要进一步的研究来确定。

        附原文:Abstract IL-35 is a relatively new cytokine that emerges as an important immunomodulator. IL-35 belongs to IL-12 cytokine family that includes IL-12, IL-23, IL-27, and IL-35. These cytokines are heterodimers that share subunits and their receptors also share subunits. Whereas IL-12 and IL-23 are clearly proinflammatory cytokines, the role of IL-35 is less clear. In mice, IL-35 appears to be anti-inflammatory and to protect from autoimmune inflammatory diseases. IL-35 induces the expansion of a subset of regulatory T cells (Tregs) and Bregs and mediates theirsuppressive function and inhibits Th17 cells. It also upregulatesosteoprotegerin and suppresses RANKL, thus inhibiting bone resorption. In autoimmune rheumatic diseases, findings are conflicting, although in systemic lupus erythematosus, there is reduced function of IL-35. In psoriatic arthritis, a disease characterized by bone erosion and bone formation in peripheral joints and bone formation in spinal joints, serum levels of IL-35 were found increased in one study. Further data are required to define the exact role of IL-35 in human autoimmune rheumatic diseases.

        引自:Sakkas LI, Mavropoulos A, Perricone C, et al. IL-35: a new immunomodulator in autoimmune rheumatic diseases.Immunol Res. 2018 May 11. doi: 10.1007/s12026-018-8998-3. [Epub ahead of print]

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