风湿

强直性脊柱炎与牙周炎有关

作者:作者Öğrendik M, et al. 翻译:北医三院刘蕊 来源:中国风湿病公众论坛 日期:2017-12-26
导读

         牙周病原体可能是造成遗传易感个体发生强直性脊柱炎的原因

        摘要:

        强直性脊柱炎(AS)与牙周炎有关。在脊柱关节炎患者中抗牙龈卟啉单胞菌和抗中性普雷沃氏菌中间抗体滴度高于健康人。柳氮磺吡啶是AS的有效抗生素治疗。莫西沙星和利福霉素也被发现是非常有效的。病因学假说表明口腔厌氧菌如卟啉单胞菌属和普雷沃氏菌是导致AS的原因。这些细菌已经在AS中被鉴定出来了,我们将就我们对这种疾病的认识来讨论它们的致病性质。牙周病原体可能是造成遗传易感个体发生AS的原因。这一发现应该能为AS的发生发展提供更全面的解释,并指导更有效的治疗策略。

        附原文:

        Abstract Ankylosing spondylitis (AS) is associated with periodontitis. Anti-Porphyromonas gingivalis and anti-Prevotella intermedia antibody titers were higher in patients with spondyloarthritis than in healthy people. Sulfasalazine is an effective antibiotic treatment for AS. Moxifloxacin and rifamycin were also found to be significantly effective. The etiology hypothesis suggests that oral anaerobic bacteria such as Porphyromonas spp and Prevotella spp contribute to the disease. These bacteria have been identified in AS, and we will discuss their pathogenic properties with respect to our knowledge of the disease. Periodontal pathogens are likely to be responsible for the development of AS in genetically susceptible individuals. This finding should guide the development of more comprehensive and efficacious treatment strategies for AS.

        引自Öğrendik M1.Oral Anaerobic Bacteria in the Etiology of Ankylosing Spondylitis.Clin Med Insights Arthritis Musculoskelet Disord. 2017 Jun 12;10:

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