风湿

IgG、IgM型抗凝血酶原抗体相关

作者:翻译:北医三院李欣艺 来源:中国风湿病公众论坛 日期:2017-09-11
导读

         高浓度的IgG、IgM型抗凝血酶原抗体与复发性自发流产相关。我们认为抗凝血酶原抗体在此疾病的病因及机制中起到一定作用。

        摘 要

        背景:抗磷脂抗体与复发性流产相关,但是临床相关的抗凝血酶原抗体与复发性流产的关系仍存在争议。本研究旨在评估血浆抗凝血酶原抗体浓度(IgG、IgM、IgA型)与复发性自然流产之间的关系。

        方法:该回顾性病例对照研究中,我们检测100例孕8-12周、既往有复发性流产病史患者的血浆抗凝血酶抗体浓度。这些患者复发性流产与抗磷脂抗体综合征无关。对照组为200例健康、妊娠年龄相匹配且无复杂妊娠情况的女性。

        结果:既往有复发性流产患者的血抗凝血酶原浓度显著高于健康对照组(分别是7.97KU/L、2.08KU/L,P<0.001)。同样的IgM型血凝血酶原抗体浓度显著高于健康对照组(5.73KU/L,1.83KU/L,P<0.001)。IgA型抗凝血酶原抗体在两组中未见显著差别。

        结论:高浓度的IgG、IgM型抗凝血酶原抗体与复发性自发流产相关。我们认为抗凝血酶原抗体在此疾病的病因及机制中起到一定作用。

        原 文

        Abstract

        Background: Antiphospholipid antibodies are associatedwith recurrent fetal loss, but the clinical relevanceof antiprothrombin (aPT) antibodies remains controversial.This study was designed to evaluate the relationshipof plasma concentrations of aPT antibodies (IgG,IgM, and IgA isotypes) and recurrent spontaneous abortion(RSA) not associated with antiphospholipid-antibodysyndrome.

        Methods: In this retrospective case– control study, wemeasured plasma aPT antibodies in 100 pregnantwomen at 8–12 weeks of gestation who had histories ofrecurrent abortion not associated with antiphospholipid-antibody syndrome. The controls were 200 healthygestational-age–matched women with uncomplicatedgestations.

        Results: The mean (SD) plasma aPT concentrationswere significantly (P <0.001) higher in women with histories of recurrent abortion than in healthy controls[7.97 (0.79) and 2.08 (0.07) kU/L]. Similarly, the concentrationsof IgM aPT were significantly (P <0.001) higherin patients than in controls [5.73 (0.85) and 1.83 (0.05)kU/L]. No differences were found for IgA aPT (P=0.358).

        Conclusions: High concentrations of aPT antibodies(IgG and IgM isotypes) are associated with pregnancyloss in women with RSA. We suggest that the antibodiesmay have a relevant role in the etiology and pathogenesisof the condition.

        引自:Laura Sabatini,1 Michela Torricelli,2 Valentina Scaccia Increased Plasma Concentrations ofAntiprothrombin Antibodies in Women withRecurrent Spontaneous Abortions.Clinical Chemistry,53:2228–232 (2007).

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