风湿

抗Ro52阳性而抗Ro60阴性与结缔组织病

作者:作者:MurngSHK et al. 翻译:北医三院赵金霞(zhao-jinxia@163.com),发布/审校:柴静 来源:中国风湿病公众论坛 日期:2017-08-11
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         前沿进展 | 抗Ro52阳性而抗Ro60阴性与结缔组织病相关

        目的:传统观点认为抗SSA/Ro是针对Ro52和Ro60抗原的自身抗体。通常抗SSA/Ro阳性包括Ro52+Ro60+或Ro52-Ro60+。抗Ro52阳性抗Ro60阴性(Ro52+ Ro60-)常不被报告。本研究在于分析这些自身抗体在结缔组织病处理中的潜在意义。

        方法:作为NHS格拉斯哥和克莱德(GGC)免疫实验室抗可提取性核抗原抗体评价服务的一部分,对Ro52+Ro60-结果进行回顾性分析。分析97例Ro52+Ro60- 和100例Ro52+Ro60+患者的临床和实验室资料。

        结果:71例(73%) 抗Ro52+Ro60-的患者被诊断为自身免疫性疾病包括未分化结缔组织病(n=14, 14%),系统性红斑狼疮(n=10, 10%),干燥综合征(n=10, 10%) 和类风湿关节炎(n=13, 13%)。23例(24%) 抗Ro52+Ro60-的患者无自身免疫性疾病的临床表现但是具有明显的临床病症包括恶性肿瘤。与之相比,87例 (87%) 抗Ro52+Ro60+ 患者具有自身免疫性疾病包括干燥综合征(n=34, 34%),系统性红斑狼疮 (SLE; n=23, 23%),未分化结缔组织病(n=12, 12%) 和类风湿关节炎 (n=6, 6%).

        结论:抗Ro52阳性而抗Ro60阴性(Ro52+Ro60-)也应该报告。大部分具有这些自身抗体的患者与各种自身免疫性疾病相关。抗Ro52+Ro60-也可以见于肿瘤等其他疾病,这些患者可以无任何自身免疫病的相关表现。

        附原文:Abstract AIMS:Autoantibodies targeting Ro52and Ro60 antigens are historically reported as anti SSA/Ro. In general antiSSA/Ro results are either anti Ro52+Ro60+ or anti Ro52-Ro60+ antibodies. AntiRo52 without anti Ro60 (Ro52+ Ro60-) antibodies are often not reportedroutinely. This study intends to review the potential significance of theseautoantibodies in the management of connective tissue diseases.METHOD:Aretrospective survey of Ro52+Ro60- was carried out as part of the serviceevaluation of extractable nuclear antigen antibodies (ENA) reporting from theimmunology laboratory, the NHS Greater Glasgow and Clyde (GGC), UK. Theclinical documents and laboratory results of 97 patients with Ro52+Ro60- and100 patients with Ro52+Ro60+ were reviewed.RESULTS:Seventy-one patients (73%)with anti Ro52+Ro60- antibodies have been diagnosed with autoimmune conditionsincluding undifferentiated connective tissue diseases (n=14, 14%), systemiclupus erythematosus (n=10, 10%), Sjögren'ssyndrome(n=10, 10%) and rheumatoidarthritis (n=13, 13%). Twenty-three patients (24%) with anti Ro52+Ro60-antibodies have no autoimmune features but were found to have significantclinical conditions including malignancies. In contrast,87 patients (87%) with anti Ro52+Ro60+ antibodies have autoimmune conditionsincluding Sjögren'ssyndrome(n=34, 34%), systemic lupuserythematosus (SLE; n=23, 23%), undifferentiated connective tissue diseases(n=12, 12%) and rheumatoid arthritis (n=6, 6%).CONCLUSION:Anti Ro52 withoutanti Ro60 (Ro52+Ro60-) antibodies should be reported. In the majority ofpatients these autoantibodies were associated with various autoimmune diseases.Anti Ro52+Ro60- antibodies were also found in patients with significantclinical conditions including malignancies even though there was no suggestionof autoimmunity at the time of testing.

        引自:MurngSHK,ThomasM.Clinicalassociations of the positive anti Ro52 without Ro60 autoantibodies:undifferentiated connective tissue diseases.J Clin Pathol.2017 Jun 29. pii:jclinpath-2015-203587. doi: 10.1136/jclinpath-2015-203587. [Epub ahead ofprint]

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